Breast and ovarian cancers: Larger study improves estimates of genetic risk

These findings will help doctors improve their advice and counselling they give for possible treatments and reducing risks through lifestyle changes.

Lead author Antonis Antoniou, Ph.D., of Cambridge’s Department of Public Health and Primary Care, said,

“We have been able to provide the most precise estimates of age-specific risks to date. These should provide more confidence in the counseling and clinical management of women with faults in the BRCA1 and BRCA2 genes.”

Cancer develops mainly from changes to genes that regulate how cells work, grow, and divide, causing them to get out of control.

Some of the genetic changes that lead to cancer can be inherited, others arise during a person’s lifetime, due to either copy errors or environmental factors – such as exposure to tobacco smoke or radiation – that can damage your DNA. …more

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