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eu: Sex and gender in bio medicine and health research



Roadmap for implementation of sex and gender into biomedicine and health research in Europe

The overall objective of EUGenMed is to improve the health of European citizens, women and men, by improving biomedical and health research through a sex and gender (S&G) sensitive approach. For this purpose we will develop a Roadmap to implement sex and gender into European biomedicine and health research. The Roadmap is the main output of the EUGenMed Project.

Definition – the Roadmap

The Roadmap includes all steps of the EUGenMed project, all materials that were discussed and generated during the project in a true spirit of openness, transparency and inclusiveness and a number of suggested implementation steps that shall take place after finishing the project. The core element of the Roadmap is a comprehensive document that summarizes the findings of four workshops in a precise and coherent manner with a number of appendixes in different formats (flyers, ppt sets), as well as recommendations for implementation of sex and gender aspects in bio medicine and health research for different target audiences.

The Roadmap was developed in four workshops, in specific areas that were chosen in a complementary manner to cover important fields in bio medicine and health research: clinical medicine and pharmacology, public health and prevention, basic research, medicines regulation and medical education.

The workshop (WS) themes were developed in such a way as to support each other. However, WS documents will be written so that they can be used and understood on their own. They will be made available to the target groups/stakeholders soon after the conference. The entire Roadmap with supporting materials will be published at the EUGenMed website

health research in Europe

Overview on the EUGenMed steps leading to the elements of roadmap:

Assembly of Stakeholders and Target audiences, communication structure, networks

Stakeholders in Gender Medicine or target audiences for our measures have been assembled by systematic searches and a large number of them has been involved in the kick-off conference and the four workshops: medical doctors and (bio) medical societies, researchers, teachers and students in academia, industry, pharmaceutical companies, science funding organizations, regulatory bodies, health policy makers, patient organisations, representatives of civil society and lay people.

Developing a road map strategy at the kick-off conference:

At the kick-off meeting we agreed a strategy with definition of focal areas of work, materials to be generated and target audiences. We defined our main working fields: clinical medicine and pharmacology, public health and prevention, basic biomedical research, medicines regulations and medical education and organized workshops in these fields.

Generation of Road map materials in four workshops (see appendix)

The generation of roadmap materials, timelines and measures for implementation of sex and gender aspects in biomedicine and health research for different target audiences took place in four workshops. We choose cardiovascular diseases (CVD) as a topic for an overarching case study and it was therefore covered in all four workshops. As a result, publications will include differences in clinical CVD and in its treatment (WS 1), in its risk factors (WS 2), its pathophysiological bases (WS 3), in medicines regulations and in medical school teaching (WS 4). The WS outputs, available from our home page in form of reports, slide sets and policy briefs, will be presented and discussed at the final conference (see appendix) and will be published as papers.

Goals of the final conference

The final EUGenMed conference will present the Roadmap and its different steps to the stakeholders, present the workshop findings and recommendations and discuss how we can all work together and with wider stakeholder groups to realize the EUGenMed goals after the project has finished.

Engagement of stakeholders

We will engage stakeholders in the process of further communication and dissemination of results to reach our objectives agreed at the Kick-off conference. All stakeholders will be encouraged to take the recommendations forward in their field of action.

Structures for sustainability

The project outline of EUGenMed asked for creating structures that will allow for sustainability of the project after the end of funding. We shall set up a working group that has the potential to generate new funding opportunities and continue to realize the recommendations of the roadmap. In the initial project we envisaged a European Gender Medicine Network, as the successor of EUGenMed. We will propose a structure to continue the EUGenMed work and involve an even wider groups of stakeholders.

Future steps towards implementation

Continuation of group meetings and meetings with wider stakeholders in structures to be defined and ensure further publications, updated information and dissemination of papers, policy briefs, fact sheets. Providing free access to materials for dissemination and communication of gender aspects to others, including slide sets via homepage.

Inclusion of gender knowledge into medical teaching in as many institutions as possible by providing learning materials/modules for this purpose. Cooperation with industry to include research for sex differences into their research and development. Discussion with funding agencies to include sex and gender into their research calls. Discussion with European agencies and institutions to include sex and gender into their guidelines and programs.

Appendix: Main workshop results

WS 1: Sex and gender in clinical medicine and pharmacology
The EUGenMed WS 1.1 workshop group assembled 20 experts that have made significant contributions to the field of clinical gender medicine. They were identified in our kick-off conference and selected based on their previous contributions in the field and in order to cover a broad spectrum of topics of work and nationalities. The group acknowledged in intense discussions that in many diseases well-described differences in etiologies and clinical presentation exist between women and men. However, this knowledge is dispersed and incompletely translated into clinical practice and research programs. The highest density of evidence based knowledge is available for cardiovascular diseases(CVD). The EUGenMed WS 1.1 groups therefore decided to focus first on CVD and to summarize the gender related findings from the other disciplines under a different aspect.
We briefly summarized our major findings related to CVD: Ischemic heart disease in the presence of non obstructed epicardial coronary arteries is more common in women than in men. Diagnostic algorithms for coronary artery disease (CAD) that perform well in men are less suitable for low and median risk middle aged women. Tako tsubo syndrome and spontaneous coronary artery dissection endanger predominantly women and may be related to hormonal changes. Remodelling in myocardial hypertrophy and HF differs in women and men, with more concentric hypertrophy and less fibrosis in women. Women have unique biological life events, menopause, pregnancy, breastfeeding which may alter their risk of CVD and response to therapies.

Sex differences in pharmacology is a major issue. Sex differences in pharmacokinetics determine bio availability of CV drugs. Sex differences in pharmacodynamics may be based, among other factors, on sex specific ion channel expression and regulation. Even so a number of differences are well known they are incompletely integrated into drug development and testing.
The group contributed to five policy briefs that are coordinated by the European Institute of Women’s Health (EIWH). We suggested inclusion of some the facts listed above for CVD in a more general manner, e.g. stroke occurs more frequently and with a different pathophysiology in women, diabetes is a more severe risk factor for CVD in women than in men, that asthma and lung cancer have different risk factors and manifestations in women and men.
In conclusion, we provided evidence that a more stringent consideration of S&G differences in CVD will lead to better understanding of pathophysiology and more personalized therapeutic approaches. We provide data suggesting that gender specific mechanisms play a role in many other diseases than CVD and just need more gender sensitive analysis.

Workshop outcomes and further steps towards implementation

The participants recognized the necessity to communicate their knowledge to a broader scientific community, to present findings at congresses, to publish summaries, to present knowledge to medical societies and be included in their guidelines and to include knowledge to medical students and health care professionals in a structured manner. As a consequence, they decided to publish 2 papers and to contribute to the eGender learningprogramme that is built for medical students and HC professionals. Sessions were submitted and accepted for the ESC congress London 2015. Furthermore, cardiovascular disease was integrated into the IGM congress September 2015 in Berlin. Next steps may be submission of sessions to OSSD congress 2016 and ESC 2016.

  • Publication: Gender in CVD, V. Regitz-Zagrosek et al, submitted
  • Publication: Transdisciplinary criteria for the inclusion of sex and gender into diagnostic algorithms, Oertelt Prigione et al, in preparation
  • Contributions to ESC meeting 2015 London; 3 sessions with gender topics in clinical field
  • Planning sessions at congress of the International Society for Gender Medicine in Berlin, Sept 2015 ( )
  • Submitting sessions with cardiovascular gender topics for OSSD 2016, DGK 2016, ESC 2016
  • Contributions to 5 policy briefs on CVD, Stroke, Diabetes, Asthma and Lung Cancer 

WS 2: Sex and gender in public health and prevention


In accordance with the general structure of the project, WS 2 was also designed to include the largest possible number of stakeholders in the field. This appears most significant for the field of public health, which includes practitioners from diverse backgrounds, and fields of activity. Hence, a significant additional effort was made to identify and invite experts beyond the participants of the kick-off conference. The WS included 22 participants covering all stakeholder areas (researchers, policy-makers, politicians, advocacy groups, funding bodies, WHO and European Commission representatives, media and communication actors).

The workshop was then structured into two main blocks, one on knowledge, where available but frequently unstructured information was to be assembled and one on implementation, where diverse experiences and expectations were summarized and analyzed to produce a systematic catalogue of practical steps for the use in different public health domains. Furthermore, the process of generating this knowledge and ‘doing gender medicine’ was also analyzed, paying particular attention to the ways in which sex and gender are redefined in this process.


Non-Communicable Diseases (NCDs) such as cardiovascular diseases (CVD), cancers, chronic respiratory diseases and diabetes, are a major global health concern and the leading cause of premature death (more than 40% of them occurring before the age of 70 years) and disease burden, both worldwide and in Europe.

Modifiable risk factors, such as tobacco smoking, unhealthy diet, physical inactivity and alcohol use contribute to the majority of NCDs. Adopting an integrative approach to health and a broad understanding of risk factors, we chose to not only focus on these modifiable risk factors, but also on mental health due to its strong relations with NCDs, on obesity insofar as it is both a condition and a risk factor, and on work which is both a protective and a risk factor. Addressing highly prevalent and relevant NCD risk factors is a significant public health and primary prevention topic, relevant for a large range of conditions. Gender-sensitive interventions are likely to contribute to an increased efficiency of interventions.
For women and men, most NCD risk factors show distinct associations with NCDs, such as with CVD, and population attributable risks differ considerably for men and women. Furthermore, from a life course perspective, first manifestations of cardiovascular diseases differ in men and women, with men being more likely to develop coronary heart disease as a first event, while women are more likely to have cerebrovascular disease or heart failure as their first event, which may be explained partly by a different lifetime pattern of risk factors.

Risk factors have to be conceptualised as influenced by factors intersecting with sex and gender, relating them to culturally driven gender norms, socio-economic position, behavioural factors, genetic make-up, levels of susceptibility, exposure time to risk factors, differences in knowledge and risk perceptions, access to health care and health care seeking patterns, health systems responses (control and management).
Major publications, even when displaying detailed sex-specific data, do not address sex and gender aspects, and there is a paucity of sex- and gender-specific recommendations for prevention. Likewise, although a number of gender sensitive Public Health Policies have been developed and implemented in the last two decades (WHO, 2012; UN General Assembly, 1997), research on impact and efficiency of such approaches and on risk factor control and management is very scarce and there is a lack of critical discussion on methodology of gender sensitised interventions.

The workshop brought together the best evidence concerning sex and gender aspects of NCD risk factors, identified examples of effective interventions, pointed out current research gaps and formulated steps for implementation in public health practice that will be discussed with stakeholders.

Workshop outcomes and further steps towards implementation

Within the WSs the need for differentiated approaches to implementation was emphasized and all stakeholders agreed upon the need for a concerted systemic and multi level approach.

Significant current hurdles are represented by an insufficient coordination between research, politics and organizations hampering concerted actions on well-defined priorities within the field of sex and gender research and practice. Based on written and oral feedback from all involved stakeholders, structured steps for the implementation at different process levels are being assembled in order to initiate, advance or finalize the implementation of gender sensitive policy and practice in public health.

  • Publication: Sex and gender aspects of risk factors for non-communicable diseases across Europe, V. Elisabeth Zemp-Stutz, Ineke Klinge et al, in preparation
  • Publication: Doing gender medicine: Reflections on sex and gender in medicine and public health, Lucie Dalibert, in preparation
  • Publication: Implementation steps towards gender-sensitive policy and practice, Sabine Oertelt Prigione, in preparation
  • Planning sessions at congress of the International Society for Gender Medicine in Berlin, Sept 2015 (
  • Submitting abstracts to Gender Summit 2015, EUPHA 2016 and EASST 2016.
    WS 3: Sex differences in basic research


    The EUGenMed WS 1.3 workshop group assembled 20 experts that have made significant contributions to the field of sex differences in basic research and were identified in our kick-off conference, with the aim to assure of broad coverage of different topics and views from different European nations. The group acknowledged in intense discussions that in a large number of animal models and most cell culture systems, significant differences exist between male and female cells and animals.
    However, this knowledge is dispersed and incompletely translated into research programs and methodological difficulties hamper the progress. The group decided to develop concepts at 3 levels: improvement of knowledge, in methodology, and networking.


    With the consideration of sex differences in cells, tissues and organs basic research has reached an exciting new dimension. The individual clinical care of patients can only be as good as the knowledge brought up by basic research approaches which deal consciously with sex differences at genetic and molecular levels. Both the differences between the sexes and the alterations that arise with age are of great importance for a society with increasing life expectancy. On the other hand, determinants affecting the unborn child are of particular importance for basic researchers. An enormous number of questions regarding sex differences remain unanswered. Two main research questions are central: The first is about the contributions of sex chromosomes and sex hormones on sex differences in cellular function and the second deals with periods of susceptibility for cardiovascular risk factors.

    Basic research feeds directly into drug development. CV drug development is getting more and more difficult and costly. We need new approaches to replace the “one size fits all” model by targeted, sex specific approaches that will lead to an improved and S&G sensitive understanding.

  • The WS discussed possible underlying mechanisms like the interaction between sex chromosomes and sex hormones with respect to sex differences in gene regulation depending on genetic variants and epigenetic processes. Examples for translational approaches were mentioned like the development of anti-arrhythmic drugs based on proteomic results concerning sex differences of ion channel expression leading to arrhythmias. Furthermore participants made reference to the progress in developing modified estrogen receptor drugs (SERMs) and the sex specific effects of PDE 5 inhibitors.
  • The discussants agreed that methodology is a major issue. They discussed the use of primary cells and cell lines of both sexes for in vitro experiments, use of animals of both sexes in disease models, transgene- or knock-out animal models genetically unique to sex, use the four core genotype (FCG) mice to provide insights into the action of sex chromosomes and perform micro array sequencing, RNA sequencing and
    GWAS with respect to both sexes.
  • The group discussed basic research aspects that could play a role in CVD, stroke, diabetes and lung cancer and contributed them as open needs for further research to the policy briefs.
  • Workshop outcomes and further steps towards implementation
  • The participants recognized the necessity to communicate their knowledge to a broader scientific community, to present findings at congresses, to publish summaries and to enter knowledge into guidelines. The vision is to act together with the International Society of Gender Medicine (IGM), the Canadian Heart Research Centre (CHRC) and the American Organization for the Study of Sex Differences (OSSD). S&G
    should be integrated in basic research projects, as in RADOX. The group decided to publish a review paper S&G specific data and methods in basic research. In the preparatory phase, sessions were submitted to the European Society of Cardiology (ESC) congress and 1 session with gender specific basic research topics will be held at ESC in London. Furthermore, sex differences in basic research were integrated into the IGM
    congress September 2015 in Berlin. Next steps may be submission of sessions to OSSD congress 2016 and the basic research congresses of ESC 2016 and AHA (BCVS).
  • Publication: Gender in Basic research, V Regitz-Zagrosek et al in preparation
  • Contributions to ESC meeting 2015 London; a sessions with basic research gender topics
  • Planning sessions at congress of the International Society for Gender Medicine in Berlin, Sept 2015 ( ): epigenetic mechanisms in sex differences, sex differences in cells,
  • Submitting sessions with basic research topics for OSSD 2016, IGM 2017
  • Contributions to 5 policy briefs on CVD, Stroke, Diabetes, Asthma and lung cancer
  • WS 4a: Medical Education


    The EUGenMed workshop 4a and 4b brought together over 40 experts from a broad range of stakeholders:

  • Representatives from the regulatory body, the European Medicines Agency; national Ethics committees; European Good Clinical Practice organisation; Commission officials; healthcare professionals in various disciplines from the European and national level; patient organisations, academics and researchers in education and communication; and the pharmaceutical industry.
  • Results

  • The Workshop 4a acknowledged that over the last 10 years the importance of sex and gender in medical research and treatment of medical conditions has been increasingly recognised. However, the need for integration of this knowledge into medical education curriculum still remains a challenge. Acknowledging the impact of sex and gender differences, increases the quality of health care provision. A patient-centred evidence-based sex and gender perspective is required throughout medical curricula including graduate programmes, medical programmes, nursing, rehabilitation, and pharmacy, continuing medical education and continuing nursing education across Europe.
  • Cardiovascular disease (CVD): Traditionally regarded as a male disease, CVD is the number one killer of women worldwide. The risk of CVD in women is still often underestimated in the medical community and in women themselves. Incorporating information generated from the growing discipline of sex and gender based medicine in educational and training programmes improves access to high quality health care and
    thereby will improve patient outcomes.
  • The regulation of medical education in Europe is the responsibility of individual Member States not the European Union (EU). The European Commission has passed legislation relevant to the medical community, such as the mutual recognition of professional qualifications, and is participating in a number of efforts to synchronize the education systems across Europe. However, detailed regulation as well as the assessment
    and evaluation of curricula remains the remit of individual Member States which has its own set of standards and regulations for medical education.
  • There is no direct mandate to coordinate medical education at an EU-level. However, most Member States collaborate in the Bologna Process and are bound by EU Directive 2005/36/EC to provide some form of regulation. The inclusion of vocabulary such as “socio-economic realities” and the “social surrounding of the human beings” in EU Directive 2005/36/EC highlights an existing awareness to combine the clinical component of medical education with social and cultural questions. Sex and gender and diversity awareness must be included in the dialogue.
  • There are different approaches to integrate sex and gender into medical education: single courses (sometimes electives) or integrated (mainstreaming throughout the curriculum) or both. Sex, gender and diversity must be included in final objectives of programmes, as part of accreditation, in quality criteria and considered by visitation committees. Consequently a multilevel approach is needed and experts must work with each other.
  • In the final Roadmap conference we will discuss with key stakeholders how best to integrate sex and gender into medical and health professional curricula. Recommendations from the workshop on medical education will be presented for discussion and agreement at the final EUGenMed conference.
  • Suggested next Steps
  • Develop a policy paper on sex and gender in medical education. Generate accessible and inclusive publications.
  • Set up a European stakeholder group on sex and gender in medical education.
  • Educate teachers on the importance of integrating sex and gender into medical education.  Encourage interactive education.
  • Work with students to integrate sex and gender in medical education, improving medical education. Adjust curricula to improve content, focusing on well-being.
  • Improve communication of the importance of sex and gender in medical education, expanding to a wide audience. Develop a clear definition of “medical education.”
  • Promote the diffusion of best practice of integrating sex and gender into medical education using evidence to improve patient outcomes.
  • Hold a symposium on sex and gender in medical education

WS 4 b: Medicines Regulation

This Workshop discussed how to translate the scientific evidence from sex and gender research into regulatory practice. Information collected from experts in the different EUGenMed workshops suggests that translating the evidence from Sex and Gender research into regulatory practice will lead to more effective, safe and targeted medicines for all.

The Workshop identified gaps in robust analysis and available information how medicines work in women. There is a lack of data from the current medicines approval process on 50% of the population – women.  Ever since the Thalidomide tragedy in the late 1950, there has been a reluctance to include women in clinical trials. The male body has been the norm. According to Health Canada “The general assumption prevailed that women did not differ from men except where their reproductive organs were concerned and data obtained from clinical research involving men could simply be extrapolated to women.”
Medicines are safer and more effective for everyone when clinical research includes diverse population groups of all ages. Even today, women are underrepresented in many clinical trials and if included, robust analysis is often lacking, a prime example is CVD.

It is also known that women metabolize medicines differently; a recent concrete example is the sleeping pill Ambien. The US Food and Drug Administration (FDA) halved the dose for women, after the drug had been on the market for 20 years.

The new EU Clinical Trials Regulation No 536/2015 is a major step forward as it has amended the legal conditions under which clinical trials will have to be conducted in the future. As of its implementation date May 2016, the population groups for whom the medicines are intended must be included in the trial and, if certain groups have been excluded this must be justified.
Workshop outcomes and further steps towards implementation:

In the final Roadmap conference we will discuss with EMA representatives and other key stakeholders how to improve sex and gender analysis when the Agency implements the new Clinical Trials Regulation and will make this information publicly available on the EU Portal and Clinical Trial database.

Suggested next steps

  • National Ethics committees to develop guidelines that require the inclusion of women in clinical research, utilising insights from the good practice example from the Medical University of Vienna.
  • IMI-2 initiative to bring together researchers, pharmaceutical industry, the European Medicines Agency (EMA) and other key stakeholders to develop a robust methodology for subgroup analysis according to gender and age, addressing existing barriers to recruitment and retention of women and older people in clinical trials.
  • EMA together with key stakeholders to draft guidelines for the analysis of sex and gender differences in clinical trials (examples Health Canada, FDA guidelines).
  • EMA to follow FDA Snapshot initiative to make sex and age-specific data available and transparent
  • For already existing medicines improve rigorous sex- and age-specific pharmacovigilance reporting.
  • Request collection of post-marketing data for medicines use in pregnant women and develop common rules for pregnancy exposure registries.
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eu: Eugenmed – Agenda for meeting 30th June 2015



EUGenMed Final conference

“Presentation of the Roadmap”

Tuesday, 30th June 2015, 8.15-16.30 at: The Permanent Representation of the 

Federal Republic of Germany to the European Union, Rue Jacques de Lalaing 8-14,

 1040 Brussels, Belgium.

Through the establishment of a European Gender Health Network and several thematic  workshops,the European Gender Medicine Project (EUGenMed) developeda roadmap for the implementation of sex and gender in biomedicine and health research.

We produced diverse instruments (position papers, policy briefs, review papers, implementation, recommendations, slides etc.) to aid the incorporation of sex and gender within the areas of medical research, health care and policy. Now, at our final conference, we will present these products and collectively define the road for future implementation.


8.15-9.45 Registration and coffee, informal discussions with project leaders

9.45-10.00 Welcome by the official host The Permanent Representation of the 

Federal Republic of Germany to the European Union.

10.00-10.15 Welcome and representation of EUGenMed Project Partners

  • Charité: Vera Regitz-Zagrosek,
  • UM: Ineke Klinge,
  • EIWH: Peggy Maguire,

10.15-10.30 Overview on the EUGenMed Project goals – The roadmap  Vera Regitz-Zagrosek

10.30-11.45  Results from WS clinical medicine and pharmacology (1.1) and basic

research (1.3)

Chairs: Vera Regitz-Zagrosek/Angela Maas

  • Sex and gender issues in clinical cardiology Angela Maas, The Netherlands
  • Drug therapy Karin Schenck-Gustafsson, Sweden
  • Basic research Vera Regitz-Zagrosek, Germany 
  • Discussion with all stakeholders

11.45-12.45 Results from WS on public health and prevention (1.2)

Chairs: Ineke Klinge

  • Facts in public health Lucie Dalibert, The Netherlands
  • Implementation into public health practice and policy Sabine Oertelt-Prigione, Germany
  • Discussion with stakeholders

12.45-13.45 Lunch

13.45-14.30 Results from WS 1.4 –part a: medical education

Chair and introduction: Peggy Maguire

  • Medical education EIWH/ Petra Verdonk, The Netherlands
  • eGender learning at Charité Ute Seeland, Germany 
  • Discussion with stakeholders

14.30-15.15  Results from WS 1.4 – part b: Medicines regulation

Chairs and brief introduction: Hildrun Sundseth

  • Medicines regulation and gender aspects,the view of EMA: Thorsten Vetter, UK
  • Discussion with stakeholders

15.15-15.30 Coffee break

15.30-16.30 Round table: “Sustainability of a Gender sensitive roadmap for future health in  Europe”

Podium: Thorsten Vetter, Marek Glezerman, Katrín Fjeldsted, Ingrid Klingmann,

Vera Regitz-Zagrosek, Ineke Klinge, Hildrun Sundseth

Eugenmed Project sponsors

First National Sepsis Summit


First National Sepsis Summit

Minister for Health Leo Varadkar,Thurs 2nd July 2015, addressed 180 delegates at first National Sepsis Summit in Dublin Castle. Sepsis is the 10th leading cause of death worldwide, more than
bowel cancer, breast cancer, road traffic accidents and HIV/AIDS combined.

In November Minister Varadkar endorsed a National Clinical Effectiveness Guideline to tackle sepsis for all patients, both adults and children, in emergency departments and in hospital wards. This guideline, recommended by HIQA following the tragic death of Ms Savita Halappanavar. This Summit aims to raise sepsis awareness and promote full implementation of the guideline.

Minister Varadkar said: “The goal of this summit is to make sure that the new Sepsis Guideline is to put into practice in order to save lives. That’s why we have invited people from across the health service. Sepsis needs to be recognised and treated at the earliest possible stage. The
guideline is an important tool for clinicians in recognising sepsis at an early stage, and providing appropriate and timely treatment. In many cases a timely intervention can mean the difference between life and death. I am pleased that the guideline is already being implemented, and that new HIPE coding introduced in January allows us to monitor rates of sepsis cases.”

Tony O’Brien Director General of the Health Service, HSE called for full guideline implementation. “I, along with colleagues from the National Sepsis Workstream, the National Sepsis Steering Committee, NCEC and the Department call on each of us present today, as managers and leaders of our health services, to support the implementation of the Sepsis Management Guideline. The HSE is committed to safe quality care underpinned by clinical effectiveness. In the 2015 National Service Plan, we, the HSE, committed to a number of clinical effectiveness priorities. One of these is the full implementation of the National Clinical Guideline – Sepsis Management across our acute hospitals”, said Mr O’Brien. The National Clinical Effectiveness Guideline No 6 – Sepsis Management Guideline, promotes safety and higher standards in emergency departments and hospital wards. It was commissioned by the NCEC in partnership with the HSE Clinical Programmes, expert clinicians, regulatory bodies, postgraduate training bodies, private hospitals and patients.  Minister Varadkar acknowledged the significant work of Dr Fidelma Fitzpatrick for
Chairing the Sepsis Steering Committee, and the work of the National Sepsis Team within the HSE Clinical Programmes, led by Dr Vida Hamilton, in ‘in leading the guideline development group and progressing its timely implementation. He also acknowledged the work of NCEC in advancing patient safety and quality, and the Irish clinical effectiveness agenda, under the
chairmanship of Professor Hilary Humphreys.

European studies estimate that a typical episode of severe sepsis will cost a healthcare institution around €25,000.  In Ireland in 2013, approximately 60% of hospital mortality had a diagnosis of sepsis or infection. 16% of all hospital deaths had a specific sepsis ICD-10-AM diagnosis code, although sepsis may not necessarily have been the underlying cause of death.

The total number of in-patients with a diagnosis of sepsis is estimated to be 8,831 accounting for 221,342 bed days in 2013. This same year,  the mortality rate of patients with a diagnosis of sepsis admitted to an intensive care environment was 28.8%.

Scottish National Flag  shield

.scot: Health boards to reduce cancer waiting times


Health boards to reduce cancer waiting times

Health boards share over £4 million to reduce cancer waiting times after performance target drop and will help improve on diagnostic wait across country and provide local support.

In the first quarter of 2015, 91.8 per cent of patients urgently referred with suspicion of cancer began treatment within 62 days compared to 94.2 per cent in the previous three months.

Only four NHS boards met the standard of 95 per cent

The £4.05m funding comes on top of £8.5m invested over past 3 years to improve cancer services … more

Le band symptôme


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Coordonné par l’Institut européen de la santé des femmes

Le band symptom i peu develop n’import oussa dans le sein.


I remark en général par band changemen la :

  • Un grosseur ou un nodule, cé a dir un pti boul ki praré pa noram, dan le sein.

Nou doit conait que la plupar des grosseur i présent aucun dangé. Si lé récen ou pa, tout le band grosseur qui change ou ki grossi i doit etre examiné par noout docteur.

Lé abituellemen indolores, dure au toucher, avec le band bord irrégulier.

  • Grosseur ou masse dan l’aisselle
  • Un décharge par le mamelon – tout le band saignemen ou écoulemen
  • Durciemen la peau du mamelon
  • Changemen l’aréole (le parti lé foncé autour le mamelon) – effet peau de citron ou gonflemen.
  • Un l’effet peau de citron qui resemb a  un cellulite, su la po le sein. Le l’effet i pe resemb a band pores agradi et i peu done la présence d’un tumeur
  • Changement position du mamelon – cel la lé enfoncé dan la po oussa néna
  • Quan le band lavan bra i gonfle ou dan l’aisselle,lé jut au desu le band sein.
  • Band fosset
  • Quan ou gagne uncoté seulemen
  • Douleur dans le band sein
  • Quan ou pert le poi
  • Band douleur dan zo
  • Quan na band changemen dan le mamelon, come un démangeaison


Band auto examen quan ou fai tou le tem i aide aou pou remark tout band changemen

Faut examine le bd=and seun un foi par moi.


Lé mieu pou faila semaine quan ou na lé régle. Apré la ménopoz, pendan out grossesse ou si ou aléte, examin le band sein dan un dat dan le calendrié ou moin o rappel chak moi, par exemple le premié. Si zot i oubli, examine le band sein dé que ou ve rappel aou !


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Le band kiss


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Kiss le sein

Un loto examin le sein cé un bon moyen pou découv  le présence un kiss dan band sein.
Le band  kiss cé bande poches remplies de liquide ki étenden ali la taille d’un broche à la taille d’un noix.
Le band kiss i déplace facilemen quan i touche, lé durs et ronds.
Le band kiss le sein lé communs et normalemen bénins (non-cancéreux).
Alor, i doi ête vérifié par le dokteur.


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Cancer Vaginal


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Le vagin cé le passage par lequel le corps i évacue band liquides lors des règles et par lequel un fanm i donne naissance.

Le vagin i relie le col de l’utérus à la vulve.

Le cancer vaginal lé rare. 
Le cancer vaginal cé un cancer où band cellules cancéreuses i trouve dans  band tissus le vagin.



Band fanm lé âgées 60 à 70 ans lé plus affectées. Cependant, le type de cancer i peut band fanm à n’importe quel âge. Même si zot la eu un hystérectomie, zot i cour toujours le risque de développe le cancer vaginal. Comme la plupart band cancers, lé  mieux traité si ou  trouve plu tôt.


  • Saignements en dehors lé règles;
  • Urination difficile ou douloureuse;
  • Douleurs pendant les rapports sexuels;
  • Douleurs dans le zone pelvienne.


Si le cancer lé suspecté, ton  docteur i peut recourir à plusieurs examens pou en vérifie la présence. Sa i incluent un lexamen pelvien interne et un frottis vaginal. Si band cellules lé peu communes lé trouvées, ton docteur i faire une biopsie. Votre docteur devra non seulement regarder le vagin mais également les autres organes du bassin pour voir exactement où le cancer a pu commencer et là où il a pu se répandre. Ton docteur i peut vous fait aou un radio la poitrine pou voir si le cancer la répane su le band  poumons.




La chirurgie

La radiothérapie

La chimiothérapie
La chirurgie cé le traitement lé plus souvent utilisé pou toute le bastades du cancer du vagin. Le type de traitement choisi va dépen le stade du cancer, de ton lâge et de ton état de santé général.


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Ecran solaire



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Crème solaire - Écran Solaire Fo ou lire toultem le band informations ke lé dsi band tube de crème solair. Regard si le band facteur protection soleil (FPS) nena assé. Le teneur en FPS ke i figur dsi le crem solai i protège aou rienk contre band rayon UV-B. Regard si out crème solair i protège contr band rayons UV-A. Ou doi mett out crème solair 10-15 inite avan allé dan soleil. Attende pa kan out po i commence rougi, par ce ke lé tro tar.

Ou doit porte band linge i protège : chemise na gran manch, band chapo ek linette soleil. Regard si out band linette soleil i protège contre band rayon ultraviolet. Evite band lampe pou bronzé, sirtout si out po lé clér. Examine out po 1 foi par moi pou oir si nena band changement, meme kan c l’hiver.


Cancer ovarien


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ovaires_fr Band zovairescé deux pti glandes de la taille d’un olive qui produi band ovules. Lé situés chaque côté l’utérus.


Le cancer ovarien i cause souvent aucun symptôme apparent.
Le douleur lé très rare un symptôme.
Deux, trois signes d’avertissement i peu éte remarquer :

  • Saignement vaginal;
  • Gain ou perte de poids;
  • Cycles menstruels anormaux;
  • Un abdomen gonflé tout le temps. Sa lé provoqué par un accumulation de fluide, i produit souvent avec le cancer ovarien. Band gonflements temporaires lé liés au cancer ovarien.

Si i suspecte, le cancer ovarien lé souvent détecté quan i fé d’un examen pelvien. Band ultrasons i peu également ête utilisés pour détecter le cancer.
Comme i existe pas aucun dépistage pou le cancer ovarien et que le band symptômes lé imprécis, beaucoup de fanm lé pas diagnostiquées avant que le cancer ovarien lé à un stade avancé.
Le cancer ovarien n’a aucun cause connue, bien que lé plus commun chez band fanm la jamais gagne zenfants.


  • Néna aucun zenfan ou un histoire d’infertilité. Cé un facteur dangeureu lé associé au faite que le band ovaires la produit band ovules chaque mois sans période de repos apportée par la grossesse.
  • Band antécédents familiaux de cancer ovarien;
  • Quan ou néna plus de 40 ans (le plus grand risque lé situé au-dessus de l’âge de 60 ans);
  • Obésité;
  • Fanm lé déjà diagnostiquées pou un cancer le sein, intestinal ou rectal.

Le band facteurs suivants i semblent rédui le risque de cancer ovarien, car lé arrêter toutel’ovulation (le processus par lequel l’ovule lé libéré).

  • Première grossesse tôt dans out vie;
  • Allaitement;
  • Ménopause précoce;
  • Utilisation de contraceptifs oraux.

Prend le pillule i offre un avantage évident – plus l’utilisation est longue, plus l’avantage et renforcé – et sa i s’applique aussi au cancer de l’endométrium.


La chirurgie cé le traitement normal pour le genre cancer la. Sa i peut comporter l’ablation d’un ou des deux ovaires, de l’utérus et des trompes utérines. Si le cancer lé détecté bonheur, particulièrement chez band jeunes fanm, lé possible  retire seulement l’ovaire cancéreux, pou préserver la fertilité.
La chimiothérapie et la radiothérapie i gagne également ête utilisées comme traitements ultérieurs.


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Band Medecine Douce


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Bandes médecines parallèle ek band cancer féminins


Le band traitement parallèle pour le cancer i devré seulement etr uttilisé en mm tem ke band traitemen conventionnels. Na un ta de thérapeutes en médecine parallèle i va refuse de prendre un patien ke lé attein un cancer s’il li consulte pa en mm tem le docteur conventionnel.

Ek le band traitement conventionnel, nena un limite de chirurgie, chimiothérapie ek radiothérapie, un cor tolérer.

Le patien i recoi un traitement ke i porte juss dsi lo kor.

Le band traitement parallèle

Le band traitement arallèle lé utilisé en même temp la médecine conventionnelle ke i offre un approch holistique deu traitement contre le cancer. ‘Parallèe’ i v dir utilisé à la place lé otr forme de traitement. L’approche complémentaire i porte dsi l’attitude band praticien ke dsi i constitue band thérapie. Le band soins d’approche holistique i adresse le band besoin d’ordre phisik, psychologique, émotionnel ek religieux et li concentr a li pas ke dsi le situation médiacel ou bien physique. Band étude scientifuik la prouvé ke le bien-être mental i collabore au bien-être physique.

En face le défi ke lé proposé pa le cancer, le bien-être mental ek émotionnel lé menacé et c la ke le band approch psychologique come le soutien psychologique, le band technique de relaxation ek visualisation i p etr util en réduisant le stress. Le band thérapeutes parallèle ek un ta médecins i croi ke le cancer i résulte d’un affaiblissement lent du système immunataire au fil le band zannée. Tou sa la i p etre causé par band inssufisance dans l’alimentation ek le style de vi, mai tout sa la pokor été trouvé.

Un changement style de vi ou bien régime i p pas li tt sel entraine un guérison ou bien un rémission mai li p entraîne un mieux être et aide a sentir aou pli for pou amorce un guérison. Un bien-être i p amélior ek un état d’esprit pli calm i p aide a surmonte le maladi.

Na un ta demoune i v combine band thérapie et en participan au processus de quérison bana na l’impression de fair vrmt un nafer pou ensorte a zot. C un aspect ke lé importan dun amélioration ek le bien être.


Un bon alimentation i garanti pas un santé parfai, mai lé prouvé ke un alimentation non équilibré i p destabilise le cor et encourage le maladie. Un régime bien équilibré lé importan pou réduir son band chance et avoir un cancer et pou conserve son band force, surtout si si ou suiv un chimiothérapie ek dautr traitement conventionnelle contr le cancer.

Essay pas change ot alimentation en okun ca si tou sa la i convien pas ou. Adapte aou a un alimentation ke lé pa parey i p prendr un p le tem et ou doi en tenir conte de sa. Si ot nouveau régime i convien pas ou, li p fair aou plis de mal ke de bien.

  • Le régime parfé c sat i sembl aou le plis acceptable (ke lé ékilibré en protéine, glucide ek matière grasse)
  • Na 2,3 moune la besoin un p la viande et i porte pas zot bien ek un régime végétarien.

  • Na dotr lé trè bien ek un régime végétarien, alors que na dotr ke lé ftgué et i perde le poi. ”mange un p sat i plé aou” i p fai aou le pli gran bien.

  • Pren zot ten pou obtenir band conseil ek l’aide ke ou la besoin.

Le régime anti-cancéreux la été concu par le Docteur Max Gerso pou ke un bon nutrition lé capabl d’enraye le maladi.

Le régime de Gerson la été mis au poin pou sat nena cancer. C un régime extrêmement rigoureux. Li comporte band grande quantité de fruit ek le jus band légume d’origine organique

  • Plis un kilo frui ek légume lé consommé chak jour.

Band lavement café lé également utilisé pou élimine band toxines du kor. Régime la i p etre difficil et épuisan a suivr kan ou lé tt sel par ce ke li demande un ta d’effort pou fai band jus frui. Lé conseillé de fair aou par un moune pou prépare band jus fruit.

Régime la i convien pas a toute domoune i essay ali, mais na 2,3 mounes la mieu porte a zot grace a li.

Le meilleur conseil c contact ot diététicien ou bien ot docteur généraliste pou fai conseille aou su le régime ke lé mieu adapté pou ou.

Band vitamine, minerais ek enzyme

Lé prouvé ke na 2,3 vitamine ek minerai i aide le système immunatair à lutt contr le cancer et i aide ali à détruir band substance cancérigène ke trouv a zot dans la nourritur. En Grande Bretagne, le Centre d’Aide contr le cancer de Bristol na un base de donné de plis 5 000 étude au sujet de l’impact de la nutrition dsi le cancer. Na 2,3 thérapeute i croi que band enzyme c le band plis a mm pou lutte conte tte forme cancer.

Le soutien psychologique

Band traitement parallèle, tou come le soutien psychologique lé particulèremen util pou aide un moune dsi le plan mental, émotionnel ou spirituel. Pou bonpé domoune ke nena cancer, le détress psychologique i dépass un ta le souffranc phisik. Ek un professionnel en la matière, band fanm i p parle de zot crainte et aborde zot sentiment. Un conseiller i ecoutera a zot et i va aide a zot résoudr zot problème ou bien pou accept a zot.

Band technique de relaxation

La relaxation c un processus actif, c un trin ke ou fé a lopposé band momen ou ou fé rien kan ou gard télé par exemple. Un vrai relaxation i implique l’espri ek le cor, li exige un attention total et plus ou va gagn pratik a li, plis ou tir bénéfice. San ke ou na conscience, le cancer i p mettr ot cor en éta de tension permanen. Tou sa la i p ajoute a li a nimporte kel inkiétude ke i existe déjà. I existe un ta forme d’excercice ek technique. La plipar i exige band exercie pou développe la respiration, pou identifié le tension musculaire et fair partir a li. Band exercice la i aide a pense pli clairement et retrouv un vialité. Lé recommandé de fair band exercice souvent – 2 session d’un kar d’heur par jour. Na 2,3 exper en la matière de relaxation i di ke band moun ke nena cancer i devrai fair 3 session d’un demi heure par jour.

La méditation

La méditation c un facon de repose out l’espri ke i aide aou a recentre aou dan la vie quotidienne en apportant un sentiment de calm ek l’ékilibre. Mm band débutan i p ressenti un détente ek un sentimen de paix intérieure. Ou naura besoin d’un endroit silencieu pou assise aou – c le meilleu position. I vau mieux trouv un endroit ou sa ou coné ke ou sra pas dérangé pendan o moin 20 minute. Un sal obscurci i permet un plis grd détente et i va aide aou a concentr aou. Band cassette musik exprè pou la méditation lé largement disponible.

La phytothérapie

La phtytothérapi i utilise band plante (sou forme racine, feuille, tige ou bien graine) pou traite band maladi et conserv la santé. Son but c amélior band fonction naturelle du cor et restaur l’harmonie ek léquilibre. La phytothérapie i présente okun garanti pou guéri le cancer, mai li lé avéré efficace pou traite 2,3 tumeur cancéreuse. Essay pa soigne aou tt sel, surtt ek band plante ke ou la ceuille par ou mm, par ce ke na 2,3 lé toxik et dangereux.


L’homéopathie c un form popilair et ke lé accepté par la medecine parallèle. Li par du principe ke i fo guéri un maladi par le maladi la. L’idée ke le cor i p guéri tt sel si son capacité d’auto-guérison lé similé, c la base de l’homéopathie. Band remède lé donné sou un forme trédilué. Si son band substance lé t donné en plis gran quantité, bana noré pu cose band symptome ke li traite. Ban symptome i p empirer légèrement avan ke bana i améliore a zot. Le traitement homéopathique i vise a elimine le cause de la maladi et non juss le band symptome. Le band zéffé secondair de la chimiothérapievek le radiothérapie i p etr nosé, ulcère buccaux, faiblesse, dépréssion,etc… lé parfoi améliorer par un traitmenn homéopathique. L’homéopathie i p stimul aussi l’énergi, réduir l’anxiété et amélior le sommeil.

L’acupuncture ek la médecine chinoise

L’acupuncture lé basé su un médecine traditionnelle chinoise, selon lakel nou nena un force ou bien un énergi vitale ( ke i appel ‘ch’i’) ke i cirkil le long band passage ke lé désigné sou le nom de méridien. Si na 2,3 band méridien la i blok, la santé sera affecté ek 2,3 symptome ke i va développe a zot.

L’acupuncture na pour bu déblok son band passage et de ré-équilobr la santé par l’introduction band zaigui stérilisé dan band poin d’acupuncture (la plipar du ten dan band avan bra, band main, le bas d jamb ek lé pié). L’acupuncture lé utilisé dan le cadre d’la médecine conventionnel ek parallèle. Na 2,3 moune i croi ke l’acupuncture, combiné ek band traitement ke lé fé ek plante d’la médecine chinoir i p etr plis efficace contr le cancer.

L’acupuncture lé utilisé pou soulage le band douleur ke band patien nena. Li p aussi réduir band zéffé toxique band traitement anti-cancéreux comme la chimiothérapie ek la radiothérapie.





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